General Information
Steatotic liver disease in children is a diagnostic and a therapeutic challenge. The most common cause of liver steatosis is the metabolic associated steatotic liver disease (MASLD), whose importance has increased along with the obesity epidemic.
However, ruling out monogenic disorders of metabolism – potentially susceptible of specific treatment – is paramount in young patients. Research in the field has unveiled genetic and epigenetic disease modifiers, and several candidate biomarkers have been selected for non-invasive disease assessment.